Fac Medicine
 

Faculty of Medicine
Montpellier, France

 

 

Tuesday JULY 10,  2012
7-9 AM: Registration

7:30-8:45 AM: Travel Award Breakfast/Registration

9-9.15  AM: Theatrum anatomicum
Welcome and Irvine Page lecture presentation

9.15-10.15 AM: Theatrum anatomicum
Irvine Page Lecture: Elaine Sanders Bush, Vanderbilt University School of Medicine, Nashville,USA 

“A life-long journey with serotonin:  Then, now and the future“


10.15-10.45 AM: Coffee break

10.45-12.45 AM: Theatrum anatomicum
SYMPOSIUM 1
“Regulation of 5-HT neurochemistry and behavior by unsuspected “villains”: Implications for psychiatric disorders and drug abuse.”
Chair: Lynette C. Daws, University of Texas Health Science Center, San Antonio, USA

“Impact of feeding conditions on sensitivity to drugs acting on 5-HT and DA systems: Implications for drug abuse and psychotherapeutics.”
Charles P. France, University of Texas Health Science Center, San Antonio, USA

“Serotonin transporter genotype and early life stress interactions in psychiatric disorders and addiction: Are organic cation transporters to blame?”
Lynette C. Daws, University of Texas Health Science Center, San Antonio, USA

“Peripheral immune system regulation of brain serotonin homeostasis.”
Randy D. Blakely, Vanderbilt University, Nashville, USA

The proaddictive effects of stress exposure are mediated by increased serotonin transporter function through kappa receptors activation of p38alpha MAPK in the ventral striatum.” 
Abigail Schindler, University of Washington, Seattle WA, USA - NIDA Travel Awardee

12.45-2.00 PM: Lunch (1:00-2:00 Business Meeting)

2.00-4.00 PM: Theatrum anatomicum
SYMPOSIUM 2
“Putting the Pieces Together: Intergrating Dopamine, Serotonin, Reward and Aversion.”
Chair : John Neumaier, University of Washington, Seattle, USA

“Striatal 5-HT6 receptors: Opposing dopamine.”
John Neumaier, University of Washington, Seattle, USA

5-HT2AR and 5-HT2CR balance in decision-making and cocaine reward.”
Kathryn A. Cunningham, University of Texas Medical Branch, Galveston, USA

“Affective and decision functions of serotonin and dopamine.”
Molly Cockett, University of Zurich, Switzerland

The influence of serotonin-1B receptors on cocaine-abuse related behavior” 
Nathan Pentkowski, Arizona State University, Arizona USA - NIDA Travel Awardee

4-4.30 PM: Coffee break

4.30-6.00 PM  Theatrum anatomicum
"Frontiers in Serotonin Research:  Pioneers and Prodigies"
Chairs and discussants:  Page and Rapport lecturers past and present

"Postnatal antidepressant treatment vs constitutive SERT deficiency produce opposing changes in presynaptic 5-HT1A responses and emotion-related behavior in adolescent and adult mice."
Stephanie Altieri, Pennsylvania State University, University Park, PA, USA - NIDA Travel Awardee

"Decynium-22 enhances SSRI-induced antidepressant effects in mice: Uncovering new targets to treat depression."
Deana Apple, University of Texas Health Science Center, San Antonia TX, USA - NIDA Travel Awardee

"Autoinhibition in dorsal raphe is mediated by local release of serotonin."
Daniel Huereca, Wayne State University School of Medicine, Detroit, MI, USA - NIDA Travel Awardee

"Synergistic suppression of cocaine-evoked elevations in motility and cortical serotonin 5-HT2C receptor (5-HT2CR) expression by combined administration of a selective 5-HT2AR antagonist plus a 5-HT2CR agonist."
Sarah Swinford, University of Texas Medical Branch, Galveston, TX, USA - NIDA Travel Awardee

"Schizophrenia-like disruption of sensory gating by serotonergic stimulation in rats: comparison with dopamine and NMDA receptors."
Shane Thwaites, University of Melbourne, Australia - NIDA Travel Awardee

6.30 -8.30: Salle Dugès
POSTER SESSION
 with wine and cheese


Wednesday JULY 11,2012
8-9 AM: Theatrum anatomicum
Maurice Rapport Lecture: Ewan Mylecharane, University of Sydney, Australia

“Serotonin and the Australian connection: the science and the people”


9.00-11.00 AM: Theatrum anatomicum
SYMPOSIUM 3
“Serotonergic neurons and adaptative responses to emergency situations: a focus on autonomic and nociceptive systems.”
Chair : Véronica Fabre, Université Pierre et Marie Curie-Paris 6, Paris, France

“Involvement of lateral paragigantocellular serotonergic cells in nociceptive and cardiovascular processing.”
Jean-François Bernard, Université Pierre et Marie Curie-Paris 6, Paris, France

“Regulation of breathing by medullary raphe serotonergic neurons in conscious or anesthetized rodents.”
Patrice Guyenet, University of Virginia School of Medicine, Charlottesville, USA

“Central chemoreception by serotonin neurons of the raphe.”
George B. Richerson, The University of Iowa, Iowa City, USA

“Inducible, repeatable and specific inhibition of serotonergic neurons in vivo reveals their essential roles in mammalian physiology and behavior.”
Susan Dymecki , Harvard Medical School, Boston, USA

11 - 11:30 AM: Coffee Break

11:30 - 1:30 PM: Theatrum anatomicum
SYMPOSIUM 4
“Multiple facets of serotonin:placenta, blood, bone connection.”
Chair: Francine Côté, CNRS UMR 8142, Hôpital Necker, Paris, France

“Vital source of serotonin: The placenta.”
Cathy Vaillancourt, Université de Québec, Laval, Canada

“Key function of serotonin in erythrocyte production and survival.”
Edouard Kouassi, Université de Montréal, Montréal, Canada

“Serotonergic system and bone cells : New paracrine autocrine pathways.”
Corinne Collet, Hôpital Lariboisière, Paris, France

Serotonin receptor 5-HT2B potentiates interferon-y production by activating T lymphocytes.” 
Marie-Eve Koué, University of Montréal, Montréal, Canada - NIDA Travel Awardee

1:30 - 2:30 PM: Lunch

2:30 -4:30 PM: Theatrum anatomicum
SYMPOSIUM 5
“Serotonin Transporter Redux 2012.”
Chair: Kathryn A. Cunningham, University of Texas Medical Branch, Galveston, USA


A novel approach for defining the role of serotonin in drug action: SERT Ile172Met mice.”
Randy D. Blakely, Vanderbilt University, Nashville, USA

“Role of PIP2 and PLC in mediating amphetamine-evoked alterations in SERT function.”
Harald Sitte, Medical University of Vienna, Vienna, Austria

“SERT as a therapeutic target for cocaine dependence.”
F. Gerard Moeller, University of Texas Health Science Center at Houston, Houston, USA

Examining the interaction between 5-HT1B receptors and SERT.” 
Yusha (Katie) Liu, University of Washington, Seattle, USA - NIDA Travel Awardee

 

4.30-5.00 PM: Coffee break

5.00-7.00 PM Theatrum anatomicum
SYMPOSIUM 6
“Serotonin in the cardiovascular system: New findings on an old transmittter.”
Chair : Luc Maroteaux, Hôpital Pitié-Salpetrière, INSERM U839, Paris, France
Co-Chair: Stephanie Watts, Michigan State University, East Lansing, USA

"The serotonin transporter (SERT) in blood pressure regulation.”
Stephanie Watts, Michigan State University, East Lansing, USA

“The 5-HT4 serotonin receptor: Physiological and pathophysiological roles in the heart ventricle.”
Finn Olav Levy, University of Oslo, Oslo, Norway

“Role of serotonin and 5-HT2 receptors in cellular processes involved in cardiac valve remodeling.”
Laurent Monassier, Faculté de Médecine, Strasbourg, France

Refining the serotonergic contribution to central chemosensitivity.” 
Rachael Brust, Harvard Medical School, Boston, USA - NIDA Travel Awardee

7:10: Departure for Banquet

 

Thursday JULY 12, 2012
8.30-10.30 AM: Theatrum anatomicum
SYMPOSIUM 7
“New roles of 5-HT6 receptor in neuro-developmental and cognitive processes.”
Chair : Joël Bockaert, University of Montpellier, Montpellier, France
Co-Chair: Mark Millan, Institut de Recherches Servier, Croissy Sur, Seine, France

“Developmental role of the 5-HT6 receptor in neuronal migration.”
Alexandre Dayer, Geneva University Hospital, Geneva, Switzerland

“Proteomic analysis of the 5-HT6 receptor complex: Identification of a new signaling pathway underlying modulation of cognition by 5-HT6 ligands.”
Phillippe Marin, University of Montpellie, Montpellier, France

“Functional role of 5HT6 receptor in the neuro-developmental cognitive deficits seen in schizophrenia.”
Kevin C.F. Fone, University of Nottingham Medical School, Nottingham, UK

Effect of the 5-HT6 receptor antagonist, SB-399885, on cognition, hippocampal cell proliferation and protein expression in the neurodevelopmental model of schizophrenia.” 
Madeleine King, University of Nottingham, Nottingham, UK - NIDA Travel Awardee


8.30-10.30 AM: Salle des actes
SYMPOSIUM 8
“The 5-HT3 receptor system: Therapeutic potential and advantages from novel ligands.”
Chair: Nicholas Barnes, University of Birmingham Medical School, Birmingham,UK
Co-Chair : Beate Niesler, University of Heidelberg, Heidelberg, Germany

“The therapeutic potential of targeting individual 5-HT3 receptor subtypes.”
Beate Niesler, University of Heidelberg, Heidelberg, Germany

“The therapeutic potential of 5-HT3 receptor partial agonists.”
Nick Moore, AMRI Inc, Albany, USA

“Tickling the 5-HT3 receptor; molecular studies and therapeutic potential of allosteric 5-HT3 receptor ligands.”
Nicholas Barnes, University of Birmingham Medical School, Birmingham,UK

The native serotonin 5-HT5A receptor: Electrophysiological characterization in rodent cortex and 5-HT1A-mediated compensatory plasticity in the knockout mouse.” 
Nathalie Goodfellow, University of Toronto, Canada - NIDA Travel Awardee

10.30 AM-11.00 AM: Coffee break

11.00 AM-1.00 PM: Theatrum anatomicum
SYMPOSIUM 9  
“Recent advances in understanding the interaction between the glutamatergic and serotonergic systems.
Chair: Mark A. Geyer, University of California, San Diego, La Jolla, USA
Co-Chair : Adam Halberstadt, University of California, San Diego,La Jolla, USA

“Antipsychotic signaling in a 5HT2A-mGlu2 receptor heterocomplex.”
Javier Gonzalez-Maeso, Mount Sinai School of Medicine, New York, USA

Is RNA editing relevant for serotonergic transmission in the cortex in health and disease?”
Dan Urban, University of Chapel Hill, Chapel Hill, USA

“Interactive effects of 5-HT2A and mGlu5 receptors on behavior in mice.”
Adam Halberstad, University of California, San Diego, La Jolla, USA

Higher-order interactions of GABA and glutamate axons in the rat dorsal raphe nucleus visualized by array tomography.” 
Mariano Soiza-Reilly, Harvard Medical School, Boston, USA - NIDA Travel Awardee

11.00 AM-1.00 PM: Salle des Actes
SYMPOSIUM 10
“Molecular genetics of serotonin neuron development, physiology and pharmacology.”
Chair : Evan Deneris, Case Western Reserve University, Cleveland, USA

“Contribution of serotonin1A auto and heteroreceptors to depression and antidepressant response.”
David Leonardo, Columbia University, New York, USA

“Transcriptional control of serotonin neurons across the lifespan.”
Evan Deneris, Case Western Reserve University School of Medicine, Cleveland, USA

“Raphe neuron development and its perturbations by altered transcription and receptor deletion.”
Sheryl Beck, Children’s Hospital of Philadelphia, Philadelphia, USA

“Shaping patterns of serotonin neurotransmission via feedback circuits.”
Kathryn Commons, Harvard Medical School, Boston, USA

1.00-2.00 PM: Lunch

2:00 - 3:00 PM: BUSINESS MEETING FOR ALL REGISTERED

3.00-5.00 PM: Theatrum anatomicum
SYMPOSIUM 11
“From Ligand Functional Selectively to Brain Region Selectivity: Differential Pharmacological Targeting of Serotonin System.”
Chair : Adrian Newman-Tancredi : NeuroAct Communication, Castres, France
Co-Chair : Umberto Spampinato, Université Victor Seglan Bordeaux2, Centre Recherche Inserm U862, Bordeaux, France

“Biased agonism at serotonin 5-HT1A receptors : Preferential postsynaptic activity for improved therapy of CNS disorders.”
Adrian Newman-Tancredi, NeuroAct Communication, Castres, France

“Agonist-directed signaling at 5-HT2A receptors in cortex.”
Laura M. Bohn, The Scripps Reseach Institute, Jupiter, USA

“Central 5-HT2B receptors exert a differential control of mesocorticolimbic and nigrostriatal dopamine pathway activity: An in vivo microdialysis study in the rat.”
Umberto Spampinato, Université Victor Seglan Bordeaux2, Centre Recherche Inserm U862, Bordeaux, France

Characterization of serotonin neurons in the raphe based on molecular and electrophysiological identity.” 
Sebastian Fernandez, INSERM, Paris, France - NIDA Travel Awardee

2.00-4.00 PM: Salles des Actes
SYMPOSIUM 12
“Ovarian Sex Steroids and Serotonin Function.”
Chair: Alan Frazer, University of Texas Health Science Center, San Antonio, USA

“Estrogen receptor GPR30 mediates desensitization of serotonin1A receptor signaling.”
Nancy Muma, University of Kansas School of Pharmacy, Lawrence, USA

Influences of sex hormones and diminished central nervous 5-HT synthesis rate on impulse control related to reward and punishment processing in young adult females.” 
Katrin Helmbold, RWTH Aachen University, Germany - NIDA Travel Awardee

“Estradiol modulation of 5HT1A and 5-HT2A receptors and SERT in brain of female hemiparkinsonian monkeys after long-term ovariectomy.”
Thérèse Di Paolo, Faculty of Pharmacy, Laval University, Canada

“Serotonin transporter function: Interaction among ovarian steroids and antidepressants.”
Alan Frazer, University of Texas Health Science Center, San Antonio, USA

4:00 Closing Remarks and Farewell

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